The major constituent in tylophora is the alkaloid tylophorine. Laboratory research has shown this isolated plant extract exerts a strong anti-inflammatory action.³ Test tube studies suggest that tylophorine is able to interfere with the action of mast cells, which are key components in the process of inflammation.⁴ These actions seem to support tylophora’s traditional use as an antiasthmatic and antiallergic medication by Ayurvedic practitioners.

These historical and laboratory findings have been supported by a few human clinical trials using differing preparations of tylophora, including the crude leaf, tincture, and capsule. One clinical trial with asthma sufferers, found that tylophora leaf (150 mg of the leaf by weight) chewed and swallowed daily in the early morning for six days led to moderate to complete relief of their asthma symptoms.⁵ In a follow-up trial with asthma patients, an alcoholic extract of crude tylophora leaves in 1 gram of glucose had comparable effects to that of chewing the crude leaf.⁶ Another trial found similar success in reducing asthma symptoms using a tylophora leaf powder (350 mg per day.)⁷ However, the tylophora was not as effective as a standard asthma drug combination. One double-blind trial failed to show any effect on asthma for tylophora.⁸