Folic Acid
Also indexed as:Vitamin B9
Folic acid is a B vitamin needed for cell replication and growth. Folic acid helps form building blocks of DNA, the body’s genetic information, and building blocks of RNA, needed for protein synthesis in all cells. Therefore, rapidly growing tissues, such as those of a foetus, and rapidly regenerating cells, like red blood cells and immune cells, have a high need for folic acid. Folic acid deficiency results in a form of anaemia that responds quickly to folic acid supplementation.
- Reliable and relatively consistent scientific data showing a substantial health benefit.
- Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
- For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.
Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.
For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.
This supplement has been used in connection with the following health conditions:
| Used for | Amount | Why |
|---|---|---|
Abnormal Pap Smear | 10 mg daily under medical supervision |  [3 stars] Large amounts of folic acid have been shown to improve the abnormal Cervical smears of some women who are taking birth control pills. |
Birth Defects | At least 400 mcg daily | [3 stars] Supplementing with folic acid before and during the early weeks of pregnancy dramatically reduces the risk of neural tube defects. |
Depression and Folic Acid Deficiency | See a doctor for evaluation | [3 stars] Taking folic acid can help correct deficiencies associated with depression. |
Gingivitis | 5 ml of a 0.1% solution used as a mouth rinse twice per day | as Folic Acid Rinse[3 stars] Rinsing with a folic acid solution may help reduce inflammation and bleeding. |
Hyperhomocysteinaemia (Vitamin B6, Vitamin B12) | 400 to 1,000 mcg of folic acid daily, 10 to 50 mg of vitamin B6 daily, and 50 to 300 mcg of vitamin B12 daily | [3 stars] Vitamin B6, folic acid, and vitamin B12 all play a role in converting homocysteine to other substances within the body and have consistently lowered homocysteine levels in trials. |
Neuropathy (Vitamin B6, Vitamin B12) | 2,000 mcg methylcobalamin (B12); 3,000 mcg methylfolate (B9); and 35 mg pyridoxal 5-phosphate once to twice daily | [3 stars] B vitamins, and vitamin B12 in particular, may be helpful in treating various types of neuropathies. People with type 2 diabetes taking metformin should be monitored for B12 deficiency. |
Pregnancy and Postpartum Support | 800 mcg daily, beginning before pregnancy | [3 stars] Supplementing with folic acid protects against the formation of birth defects, such as spina bifida. It also may lead to fewer infections for mothers and higher birth weight for babies. |
Schizophrenia and Folic Acid Deficiency | If deficient: 10 to 20 mg a day under medical supervision | [3 stars] People with schizophrenia may have a tendency to be deficient in folic acid and they may see improvements when given supplements. |
Type 2 Diabetes | 6 mg methylfolate daily | [3 stars] Folic acid supplementation may improve blood glucose control and insulin sensitivity in people with type 2 diabetes. Folic acid also lowers homocysteine levels and preliminary evidence suggests it may help to prevent and treat diabetes complications. |
Age-Related Cognitive Decline | 800 mcg per day |  [2 stars] Folic acid has been shown to slow the rate of cognitive decline in people with high homocysteine levels and in elderly people. |
Age-Related Cognitive Decline (Vitamin B6, Vitamin B12) | Refer to label instructions | [2 stars] In women with cardiovascular disease or related risk factors and low dietary intake of folic acid, vitamin B6, and vitamin B12, supplementing with a combination of these nutrients may protect against age-related cognitive decline. |
Atherosclerosis | Consult a qualified doctor | [2 stars] Blood levels of an amino acid called homocysteine have been linked to atherosclerosis and heart disease in most research. Taking folic acid may help lower homocysteine levels. |
Breast Cancer | 400 mcg daily | [2 stars] For women who drink alcohol, folic acid may reduce breast cancer risk by reversing the damaging effect alcohol has on DNA. |
Coeliac Disease (Vitamin B6, Vitamin B12) | 3 mg vitamin B6, 0.8 mg folic acid, and 0.5 mg vitamin B12 | [2 stars] Daily supplementation with a combination of vitamin B6 (3 mg), folic acid (0.8 mg), and vitamin B12 (0.5 mg) have been shown to help relieve depression in people with coeliac disease. |
Coeliac Disease | Consult a qualified doctor | [2 stars] The malabsorption that occurs in coeliac disease can lead to multiple nutritional deficiencies. Supplementing with folic acid may correct a deficiency. |
Halitosis and Gum Disease | Use 5 ml twice per day of a 0.1% solution | [2 stars] Folic acid is often recommended by doctors to help prevent and treat periodontitis and has been shown to reduce the severity of gingivitis when taken as a mouthwash. |
Heart Attack | 500 to 800 mcg daily | [2 stars] Taking folic acid may reduce blood levels of homocysteine. High homocysteine levels have been linked to an increased heart attack risk. |
Intermittent Claudication (Alpha-Linolenic Acid, Fish Oil, Oleic Acid, Vitamin B6, Vitamin E) | 200 mg of EPA and 130 mg of DHA daily, plus small amounts of vitamin B6, folic acid, vitamin E, oleic acid, and alpha-linolenic acid | [2 stars] In one study, men with intermittent claudication who drank a milk product fortified with fish oil, vitamin B6, folic acid, vitamin E, oleic acid, and alpha-linolenic acid could walk further without pain than those who drank regular milk. |
Macular Degeneration (Vitamin B6, Vitamin B12) | 2.5 mg folic acid, 50 mg vitamin B6, and 1 mg vitamin B12 | [2 stars] In a double-blind study of female health professionals who had cardiovascular disease or risk factors, daily supplementation with folic acid, vitamin B6, and vitamin B12 significantly decreased age-related macular degeneration.
|
Migraine Headache (For a subset of people ) | 5 mg per day | [2 stars] Taking folic acid may improve migraines in people with high homocysteine levels and a certain genetic characteristic.
|
Osteoporosis and High Homocysteine | 5 mg with 1,500 mcg of vitamin B12 daily | [2 stars] Homocystinuria, a condition associated with high homocysteine levels, frequently causes osteoporosis. By lowering homocysteine levels, folic acid may help prevent osteoporosis. |
Preeclampsia | 5 mg daily | [2 stars] Supplementing with folic acid and vitamin B6 may lower homocysteine levels. Elevated homocysteine damages the lining of blood vessels and can lead to preeclamptic symptoms. |
Schizophrenia and High Homocysteine (Vitamin B6, Vitamin B12) | Take folic acid (2 mg), vitamin B6 (25 mg), and vitamin B12 (400 mcg) daily | [2 stars] People with schizophrenia who have high homocysteine levels may improve symptoms by supplementing with folic acid, vitamin B6, and vitamin B12. |
Sickle Cell Anaemia and High Homocysteine | Consult a qualified doctor | [2 stars] In one trial, patients with sickle cell anaemia who were given folic acid plus aged garlic extract, vitamin C, and vitamin E saw significant improvement and less painful crises. |
Skin Ulcers | Consult a qualified doctor | [2 stars] Large amounts of folic acid given both orally and by injection could promote healing of chronic skin ulcers due to poor circulation. |
Thalassaemia | If deficient: 250 to 1,000 mcg daily | [2 stars] Some studies have found people with thallasaemia to be frequently deficient in folic acid, taking folic acid supplements may help. |
Ulcerative Colitis | Consult a qualified doctor | [2 stars] People with ulcerative colitis may be at a higher risk of colon cancer, supplementing with folic acid may reduce the risk. |
Vitiligo | Refer to label instructions | [2 stars] Studies have shown folic acid to be effective at skin re-pigmentation in people with vitiligo. |
Alzheimer’s Disease | Refer to label instructions |  [1 star] Some researchers feel Alzheimer’s disease may be related to folic acid deficiency. |
Bipolar Disorder | Refer to label instructions | [1 star] Folic acid deficiency is associated with both mania and depression. Getting enough folic acid helps the body manufacture serotonin and other neurotransmitters. |
Colon Cancer | 400 mcg daily | [1 star] Folic acid appears to help prevent colon cancer, especially in people with ulcerative colitis and people who drink alcohol. |
Crohn’s Disease | Refer to label instructions | [1 star] Folic acid is needed to repair intestinal cells damaged by Crohn’s disease. Supplementation may offset some of the deficiency caused by Crohn’s-related malabsorption. |
Depression | See a doctor for evaluation | [1 star] Taking folic acid can help correct deficiencies associated with depression. |
Dermatitis Herpetiformis | Refer to label instructions | [1 star] Supplementing with folic acid can counteract the nutrient deficiency that often occurs as a result of malabsorption. |
Diarrhoea | Refer to label instructions | [1 star] Folic acid can help repair intestinal lining damage caused by acute diarrhoea. |
Down Syndrome | Refer to label instructions | [1 star] People with Down syndrome may be deficient in folic acid and may benefit from supplementation. |
Epilepsy | Refer to label instructions | [1 star] Folic acid may help reduce epileptic seizure frequency, people taking anti-convulsant medications should talk to their doctor before deciding whether to use folic acid. |
Gingivitis | Refer to label instructions | as Folic Acid Oral[1 star] In pill form, folic acid may improve gingivitis symptoms, although one study found the mouth rinse form to be more effective. |
HIV and AIDS Support | Refer to label instructions | [1 star] Low folic acid levels are also common in HIV-positive people, supplementing may help correct a deficiency. |
Lung Cancer | Refer to label instructions | [1 star] Together, folic acid and vitamin B12 help cells replicate normally. In one trial, smokers with precancerous lung changes who were given folic acid and vitamin B12 saw a significant reversal of their condition. |
Peripheral Vascular Disease | Refer to label instructions | [1 star] As with other vascular diseases, people with thromboangiitis obliterans are more likely to have low levels of folic acid. Supplementing with folic acid may help correct a deficiency. |
Psoriasis | Only for people who are not taking prescription drugs such as methotrexate that interfere with folic acid metabolism | [1 star] High amounts of folic acid have been shown to improve psoriasis. |
Restless Legs Syndrome | Refer to label instructions | [1 star] People with familial restless leg syndrome appear to have an unusually high requirement for folic acid. Supplementing with folic acid may help relieve uncomfortable sensations. |
Seborrheic Dermatitis | Refer to label instructions | [1 star] Supplementing with folic acid has been shown to improve adult seborrheic dermatitis. |
Stroke and High Homocysteine | Refer to label instructions | [1 star] Elevated blood levels of homocysteine have been linked to stroke risk in most studies. Supplementing with folic acid may lower homocysteine levels and reduce stroke risk. |
Thromboangiitis Obliterans | Refer to label instructions | [1 star] As with other vascular diseases, people with thromboangiitis obliterans are more likely to have low levels of folic acid. Supplementing with folic acid may help correct a deficiency. |
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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.
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