Vitamin B6
Also indexed as:B6 Vitamin, Pyridoxal-5’-Phosphate (Vitamin B6), Pyridoxine (Vitamin B6)
Vitamin B6 is the master vitamin for processing amino acids—the building blocks of all proteins and some hormones. Vitamin B6 helps to make and take apart many amino acids and is also needed to make the hormones, serotonin, melatonin, and dopamine.
- Reliable and relatively consistent scientific data showing a substantial health benefit.
- Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
- For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.
Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.
For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.
This supplement has been used in connection with the following health conditions:
| Used for | Amount | Why |
|---|---|---|
Anaemia | 2.5 to 25 mg daily for three weeks, then 1.5 to 2.5 mg per day as maintenance therapy |  [3 stars] Vitamin B6 deficiency can contribute to anaemia, supplementing with this vitamin may restore levels and improve symptoms. |
Anaemia and Genetic Vitamin B6-Responsive Anemia | 50 to 200 mg per day | [3 stars] Taking vitamin B6 may partially correct sideroblastic anaemia, although they must be taken for life. |
Autism | 30 mg daily per 2.2 lbs (1 kg) of body weight; doctor's supervision recommended | [3 stars] Research shows that vitamin B6 can be helpful for autistic children. |
Depression | 20 mg twice daily | [3 stars] Oral contraceptives can deplete the body of vitamin B6, a nutrient needed for normal mental functioning. In such cases, vitamin B6 supplementation may improve mood. |
Hyperhomocysteinaemia (Folic Acid, Vitamin B12) | 400 to 1,000 mcg of folic acid daily, 10 to 50 mg of vitamin B6 daily, and 50 to 300 mcg of vitamin B12 daily | [3 stars] Vitamin B6, folic acid, and vitamin B12 all play a role in converting homocysteine to other substances within the body and have consistently lowered homocysteine levels in trials. |
Morning Sickness | 10 to 25 mg three times daily | [3 stars] In two double-blind trials, supplementation with vitamin B6 significantly reduced the severity of morning sickness. |
Neuropathy (Folic Acid, Vitamin B12) | 2,000 mcg methylcobalamin (B12); 3,000 mcg methylfolate (B9); and 35 mg pyridoxal 5-phosphate once to twice daily | [3 stars] B vitamins, and vitamin B12 in particular, may be helpful in treating various types of neuropathies. People with type 2 diabetes taking metformin should be monitored for B12 deficiency. |
Premenstrual Syndrome | 100 to 200 mg per day on a regular basis | [3 stars] Many clinical trials show that taking vitamin B6 helps relieve PMS symptoms. |
Type 1 Diabetes | 100 to 200 mg vitamin B6 daily | [3 stars] People with diabetes may have an increased need for vitamin B6. Supplementing with the vitamin may help maintain normal levels and prevent type 1 diabetes complications. |
Age-Related Cognitive Decline | 20 mg daily |  [2 stars] There is evidence that supplementing with vitamin B6 (pyridoxine) may improve memory performance, especially in people who are deficient. |
Age-Related Cognitive Decline (Folic Acid, Vitamin B12) | Refer to label instructions | [2 stars] In women with cardiovascular disease or related risk factors and low dietary intake of folic acid, vitamin B6, and vitamin B12, supplementing with a combination of these nutrients may protect against age-related cognitive decline. |
Asthma | 100 to 200 mg daily | [2 stars] Vitamin B6 deficiency is common in asthmatics. Supplementing with the vitamin may decrease the frequency and severity of asthma attacks. |
Carpal Tunnel Syndrome | 100 to 300 mg daily for no more than three months; 50 to 100 mg daily after that | [2 stars] Vitamin B6 deficiency is common in people with carpal tunnel syndrome, supplementing with the vitamin has reportedly relieved symptoms. |
Coeliac Disease (Folic Acid, Vitamin B12) | 3 mg vitamin B6, 0.8 mg folic acid, and 0.5 mg vitamin B12 | [2 stars] Daily supplementation with a combination of vitamin B6 (3 mg), folic acid (0.8 mg), and vitamin B12 (0.5 mg) have been shown to help relieve depression in people with coeliac disease. |
Depression and Premenstrual Syndrome | Take under medical supervision: 100 to 300 mg daily | [2 stars] A few studies indicate that supplementing with vitamin B6 helps alleviate depression, including depression associated with PMS. |
Intermittent Claudication (Alpha-Linolenic Acid, Fish Oil, Folic Acid, Oleic Acid, Vitamin E) | 200 mg of EPA and 130 mg of DHA daily, plus small amounts of vitamin B6, folic acid, vitamin E, oleic acid, and alpha-linolenic acid | [2 stars] In one study, men with intermittent claudication who drank a milk product fortified with fish oil, vitamin B6, folic acid, vitamin E, oleic acid, and alpha-linolenic acid could walk further without pain than those who drank regular milk. |
Low Back Pain (Vitamin B1, Vitamin B12) | Take under medical supervision: 50 to 100 mg each of vitamins B1 and B6, and 250 to 500 mcg of vitamin B12, all taken three times per day | [2 stars] A combination of vitamin B1, vitamin B6, and vitamin B12 may prevent a common type of back pain linked to vertebral syndromes and may reduce the need for anti-inflammatory medications. |
Macular Degeneration (Folic Acid, Vitamin B12) | 2.5 mg folic acid, 50 mg vitamin B6, and 1 mg vitamin B12 | [2 stars] In a double-blind study of female health professionals who had cardiovascular disease or risk factors, daily supplementation with folic acid, vitamin B6, and vitamin B12 significantly decreased age-related macular degeneration.
|
MSG Sensitivity | Refer to label instructions | [2 stars] In one study, eight out of nine people stopped reacting to MSG when given vitamin B6. Many doctors suggest that people having MSG-sensitivity symptoms try supplementing with vitamin B6 for three months as a trial. |
Pregnancy and Postpartum Support and High Homocysteine | 750 mg daily taken under the supervision of a doctor | [2 stars] Women who habitually miscarry have been found to have high homocysteine levels. Vitamin B6 may reduce these levels and increase the chances of a successful pregnancy. |
Schizophrenia | Consult a qualified doctor | [2 stars] Vitamin B6 has been used in combination with niacin in the treatment of schizophrenia with some reported benefits. |
Schizophrenia and High Homocysteine (Folic Acid, Vitamin B12) | Take folic acid (2 mg), vitamin B6 (25 mg), and vitamin B12 (400 mcg) daily | [2 stars] People with schizophrenia who have high homocysteine levels may improve symptoms by supplementing with folic acid, vitamin B6, and vitamin B12. |
Tooth Decay | For adults: 20 mg per day in capsules or lozenges; for children: 9 mg daily | [2 stars] Vitamin B6 appears to increase growth of beneficial mouth bacteria and decrease growth of cavity-causing bacteria. |
Type 2 Diabetes | 35 mg of pyridoxal 5-phosphate twice daily | [2 stars] People with type 2 diabetes, and especially those with diabetes complication, tend to have low levels of active vitamin B6, a nutrient needed for healthy metabolism. |
Type 2 Diabetes and Diabetic Neuropathy (Vitamin B1) | 25 mg of vitamin B1 daily, with 50 mg of vitamin B6 daily | [2 stars] Taking vitamin B1 combined with vitamin B6 may improve symptoms of diabetic neuropathy. |
Vertigo | Consult a qualified doctor | [2 stars] Studies have shown vitamin B6 to be effective at reducing symptoms. |
Acne Vulgaris | Refer to label instructions |  [1 star] While not proven in research, some reports suggest that it may alleviate adolescent and premenstrual acne, however, another report has suggested that it might make acne worse. |
Alcohol Withdrawal | Refer to label instructions | [1 star] Alcohol-related anxiety may be improved by a combination of vitamin B6, vitamin C, niacin, and vitamin E, though the high amounts of niacin and vitamin B6 used in the study need a doctor’s supervision. |
Alzheimer’s Disease (Co-Enzyme Q10, Iron) | Refer to label instructions | [1 star] A combination of co-enzyme q10, iron (sodium ferrous citrate), and vitamin B6 may improve mental status in people with Alzheimer’s disease. |
Amenorrhoea | Refer to label instructions | [1 star] Preliminary evidence found that vitamin B6 restored menstruation and normalised hormone levels in three women with amenorrhoea who had high prolactin levels. |
Atherosclerosis | Refer to label instructions | [1 star] Blood levels of the amino acid homocysteine have been linked to atherosclerosis and heart disease in most research. Taking vitamin B6 may help lower homocysteine levels. |
Attention Deficit–Hyperactivity Disorder | Refer to label instructions | [1 star] In one study, high amounts of vitamin B6 was more effective than methylphenidate (Ritalin). A doctor knowledgeable in nutrition must be consulted when using high amounts of this vitamin. |
Bulimia (L-Tryptophan) | Refer to label instructions | [1 star] Vitamin B6, when taken with L-tryptophan, has been shown to improve eating behaviour, feelings about eating, and mood among women with bulimia. |
Coeliac Disease | Refer to label instructions | [1 star] For people with coeliac disease who experience depression even after following a gluten-free diet, supplementing with vitamin B6 may be beneficial. |
Epilepsy | Refer to label instructions | [1 star] Vitamin B6 has helped children with seizures related to a genetic enzyme defect. However, it is not known whether supplementation would benefit people with epilepsy. |
Heart Attack | Refer to label instructions | [1 star] Taking vitamin B6 may reduce blood levels of homocysteine. High homocysteine levels have been linked to an increased heart attack risk. |
HIV and AIDS Support | Refer to label instructions | [1 star] Vitamin B6 deficiency was found in more than one-third of HIV-positive men, deficiency was associated with decreased immune function in this group. Supplementing with the vitamin may improve survival rate. |
Hypoglycaemia | Refer to label instructions | [1 star] Vitamin B6 helps control blood sugar levels in people with diabetes, and since there are similarities in the way the body regulates high and low blood sugar levels, it might be helpful for hypoglycaemia as well. |
Kidney Stones | Refer to label instructions | [1 star] Taking vitamin B6 with magnesium can inhibit oxalate stone formation. |
Osgood-Schlatter Disease (Manganese, Zinc) | Refer to label instructions | [1 star] Some doctors have reported good results using a combination of zinc, manganese, and vitamin B6 for people with Osgood-Schlatter disease. |
Osteoporosis and High Homocysteine | Refer to label instructions | [1 star] Homocystinuria, a condition associated with high homocysteine levels, frequently causes osteoporosis. By lowering homocysteine levels, vitamin B6 may help prevent osteoporosis. |
Parkinson’s Disease | Refer to label instructions | [1 star] Vitamin B6 has been reported to improve Parkinson’s symptoms. It can be used in conjunction with L-dopa plus carbidopa (Sinemet) or selegiline (Eldepryl, Atapryl), rather than with L-dopa alone. |
Photosensitivity | Refer to label instructions | [1 star] Vitamin B6 has been used to successfully reduce reactions to sunlight. |
Pre- and Post-Surgery Health | Refer to label instructions | [1 star] In one trial, a combination of vitamins B1, B6, and B12 before and after surgery prevented post-surgical reductions in immune activity. |
Preeclampsia | Refer to label instructions | [1 star] Supplementing with vitamin B6 and folic acid may lower homocysteine levels. Elevated homocysteine damages the lining of blood vessels and can lead to the preeclamptic symptoms. |
Seborrheic Dermatitis in Adults | Refer to label instructions | as Vitamin B6 Topical[1 star] Topical applied vitamin B6 ointment improved adult seborrheic dermatitis in one study. However, oral vitamin B6 was ineffective. |
Sickle Cell Anaemia | Refer to label instructions | [1 star] Vitamin B6 has been shown to have anti-sickling effects on the red blood cells. It can also correct vitamin B6 deficiency, which is common in people with sickle cell anaemia. |
Stroke and High Homocysteine | Refer to label instructions | [1 star] Elevated blood levels of homocysteine have been linked to stroke risk in most studies. Supplementing with vitamin B6 may lower homocysteine levels and reduce stroke risk. |
Tardive Dyskinesia | Refer to label instructions | [1 star] In some studies, taking vitamin B6 along with other nutrients appeared to prevent the development of tardive dyskinesia. |
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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.
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